Lipoic acid

By Targets:	ADC Linker (1) Akt (1) Amyloid-β (1) Antibiotic (1) Apoptosis (5) Bacterial (1) Endogenous Metabolite (6) HIV (4) Insulin Receptor (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (7) NF-κB (4) NO Synthase (1) PROTAC Linkers (1) Reactive Oxygen Species (2) TrxR (1) Tyrosinase (1)
By Research Areas:	Cancer (9) Infection (5) Inflammation/Immunology (6) Neurological Disease (1)
Click Chemistry:	Azide (1)

Targets Recommended: Amino Acid Derivatives Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology Cancer
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-18733R

Lipoic acid (Standard) 5+ Cited Publications (R)-(+)-α-Lipoic acid(Standard); R-(+)-Thioctic acid (Standard)	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology Cancer
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492R

*α-Lipoic* Acid (Standard)** 5 Publications Verification Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492

*α-Lipoic* Acid** 5 Publications Verification Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

*α-Lipoic* Acid sodium** Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-157175

*Mannosamine–lipoic* acid adduct**	Others	Others
Mannosamine-lipoic acid adduct is a hapten. Mannosamine-lipoic acid adduct with hsIgG conjugation significantly reduces the antibody immune response against hsIgG .

HY-N0492S

*α-Lipoic* Acid-d5** Thioctic acid-d₅; (±)-α-Lipoic acid-d₅; DL-α-Lipoic acid-d₅	Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-141336

α-Lipoic acid-NHS

DL-α-Lipoic acid-NHS
PROTAC Linkers Cancer

α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

*α-Lipoic* acid-NHS** DL-α-Lipoic acid-NHS	PROTAC Linkers	Cancer
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-146133

LA-Bac8c	Bacterial Antibiotic	Infection
LA-Bac8c is a Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties. LA-Bac8c inhibits S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa with MICs of 1, 4, 8, 8, and 8 μg/mL .

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

HY-15453

Devimistat Maximum Cited Publications 10 Publications Verification CPI-613	Apoptosis Mitochondrial Metabolism	Cancer
Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells .

HY-147547

SV5	Amyloid-β	Neurological Disease
SV5 is a potent anti-Alzheimer agent. SV5 can significantly protect SHSY-5Y cells against Aβ_1-42-induced death. SV5 shows moderate antioxidant and good neuroprotective activities. SV5 shows the high stability in human plasma and the best pharmacological profile .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	NO Synthase	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .

HY-151655

11-Azidoundecanoic acid	ADC Linker	Others
11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling . 11-Azidoundecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

HY-146133

LA-Bac8c	Bacterial Antibiotic	Infection
LA-Bac8c is a Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties. LA-Bac8c inhibits S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa with MICs of 1, 4, 8, 8, and 8 μg/mL .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18733

Lipoic acid Maximum Cited Publications 6 Publications Verification (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-18733R

Lipoic acid (Standard) Maximum Cited Publications 6 Publications Verification (R)-(+)-α-Lipoic acid(Standard); R-(+)-Thioctic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492R

*α-Lipoic* Acid (Standard)** 5 Publications Verification Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492

*α-Lipoic* Acid** 5 Publications Verification Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

*α-Lipoic* Acid sodium** Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

Cat. No.	Compare	Product Name	Species	Source

HY-P76358

	GCSH Protein, Human (His) Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein; GCSH	Human	E. coli
	GCSH protein, a vital component of the glycine cleavage system, efficiently shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST), contributing to glycine degradation. GCSH Protein, Human (His) is the recombinant human-derived GCSH protein, expressed by E. coli , with N-His labeled tag. The total length of GCSH Protein, Human (His) is 125 a.a., with molecular weight of ~17 KDa.


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Cat. No.	Product Name	Chemical Structure

HY-N0492S

*α-Lipoic* Acid-d5**
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

Cat. No.	Product Name	Application	Reactivity

HY-P81072

LIAS Antibody HUSSY 01; LAS; LIP 1; Lip syn; LIP1; Lipoate synthase; Lipoic acid synthetase; Lipoic acid synthetase mitochondrial; Lipoyl synthase, mitochondrial; LS; MGC23245.	ELISA; IHC-P ; ICC; IF;	Mouse(predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep)
LIAS Antibody is an unconjugated, rabbit-derived, anti-LIAS polyclonal antibody. LIAS Antibody can be used for: ELISA, IHC-P, ICC, IF, expriments in mouse and predicted: human, rat, chicken, dog, pig, cow, horse, rabbit, sheep background without labeling.

Cat. No.	Product Name		Classification

HY-151655

11-Azidoundecanoic acid		Azide
11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling . 11-Azidoundecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Lipoic acid

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